Description

Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5). Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells.


Clinical trials

There are no clinical trials involving CEACAM5, however the following two clinical trials involve CEA (keep or change?).
NCT02349724 - Lung Cancer, Colorectal Cancer, Breast Cancer, Pancreatic Cancer
NCT03267173 - Pancreatic Cancer


Target gene expression

The following plot describes the expression, in different tissues and TCGA cancers, of the different isoforms of the gene CEACAM5.


Target essentiality


Protein properties

The following plot describes the target topology, highlighting the position of the endo-, ecto- and transmembrane domains, as well as the position of a signal peptide, when present. The last three rows describe the position of potential epitopes, as well as phosphorylation and glycosylation sites.